Real: Direction

34,701 notes

freedomforwhales:

im5-official:

Ahh yes, The dreaded school. When it comes around we all dread, new teachers, new schedule, some new unfamiliar faces, the MASSIVE amount of homework load, less time on tumblr. Here is another long post with a few sites and others to help you out here!

College needs:
Advice on college
Alternatives to buying expensive textbooks
AP Cram Packets
Cheat sheet for becoming an adult
Dorm room survival
Free online college classes
How to survive college masterpost
Food
cheap & healthy snacks
chocolate muffin in a mug tutorial
Coffee recipes to help stay awake
Every Starbucks drink and pasty FTW
For the vegans you bad ass motherfuckers
Herearesomedeliciousfood
macaroni cheese / mac&cheese in a cup
quick and easy soup recipes
study snacks
Study snack
thousands of quick and easy snack recipes
Yummy cheesiness!
40 on-the-go breakfast recipes
Helpful sites:
Challenge your brain
Feed the hungry while using your vocabulary
Free online textbooks
Grade calculator
Quizlet
Rape Escape
Whole page dedicated to studying/organizing
High school needs:
For Juniors or Seniors With Low Income Families Looking For Scholarships
How to survive freshman year
Mental health resources:
a website that is always relevant.
falling asleep tips
How long to sleep
how to talk to and help an anxiety-ridden friend
how to wake up in the morning
keep taking your mind off of it
mental illness recovery tips
need a motivational speech? i like this one for myself.
not having a good day? :c
picking up a hobby can relax you during the school year!!
seriously just please try to relax ily
take your mind off of it
tips on self-love
when to go to sleep/wake up
working out is a total stress-buster.
Misc resources:
download free books
express yourself with make-up 
Hobbies masterpost
I fucking love to study to this.
please remember this.
Sick ass movie list I have more but, this is a school one so message me for more.
Sites to help you not get distracted with other sites. (Mac)(PC)
Various ways to where a scarf
What’s the fucking weather
Motivation:
earn a cute kitten picture after writing
how to get motivated
Procrastinator? 
Music/Sound:
calm/nature sounds
chill playlist
coffee shop blues
coffee shop sounds
concentration playlist
relaxation
study playlist
4hours of classical music
School resources:
An already typed essay at your fingertips(type the subject and press random stuff and an essay forms. TO KIND OF HELP)
bibliography maker
educational links fucking galore
my favorite tutoring website
online ruler
pull an all nighter but do well on your exam
Social media citing
study like a college kid
Time Management
Psychology Lectures by a Professor from Yale University
Stress relief:
Calm
compliments generator
how long to nap
go to a quiet place
learn more about anxiety.
panic and anxiety information masterpost
Relaxation techniques
Stress Analyst
the thoughts room
take a guided relaxation
yoga poses
Studying/school help:English/History:
Best place to get help for English
essay structure guide
essay writing help
free microsoft word alternative
Grammar and spell checker
Graphic Essay Organizer
Help on reading/researching
Make a kick ass essay
Masterpost of writing software
microsoft word equivalent
more essay writing help
On books you you don’t want to read
Tip of my tongue
Foreign Languages:
Learn, Spanish, French, English, Portuguese, German, Italian
Geography:
learn geography
Math/Science:
calculators (includes graphing, geometric, stats etc)
College/high school Chemistry notes
math problem solver (2)
Periodic Table
Thinking/memorizing
This is the math god
Study Needs:
Answers to the textbook
Beneficial studying tips
Crash course in any subject with John Green
Free Educational resources for anyone and everyone 
help in a ton of subjects
Helps you in any subject
homework help
how to google
how to study, Study guide
finals survival guide
improve your studying skills
Learning Websites Masterpage
Looking for a word
make flash cards
One of the best learning websites
Scholarpedia
Tips before/during an exam
Tips on Exams
TIPS:
Remember that today’s day in age is different from how it was back then. So don’t stress about school too much.High school students today have the anxiety of what a mental patient in the insane asylum had in the 50s. Here’s also a thing to show how times have changed.
Prioritize. List what needs to get done first and when. Sometimes getting the bigger/harder tasks is easier than conquering the smaller/easier tasks.
Set times when certain projects need to be done and stick to that deadline.
Turn your phone off or give it to your parents while doing work/studying. I know that we live in the age of technology and literally everything is at the touch of our fingertips. Honestly though you can wait on what your favorite celebrity has to say or if your crush liked your instagram photo. You’ll be more involved in that than you are into your work.
If you have trouble in a certain subject and there is no assigned seating, take advantage of the front. I guarantee you’ll learn more.
Ask your teacher what exactly you’ll need to know. If you’re taking notes during the year, write in the margins whether or not it will be tested. It will be easier to know what you will be tested on.
Save your exams. Half the time your teachers use the same questions (or questions similar) from your exams on your midterms or finals.
Don’t try to do homework straight afterschool if you can’t, despite what everyone says. Give yourself an hour, and try to get some exercise in. I find it stops me getting bored of sitting down. Not to mention helps me concentrate better.
Don’t just read the material, write it, draw it, recite it, quiz yourself on it! Until you have the material down.
Join clubs, sports, or organizations! You’re guaranteed to find friends in there. You’ll already have common interests. Start with that and go with the flow.
College kids: If you don’t have assigned seating, and you have been sitting in the same seat for 2 weeks. That is you assigned seat now. Don’t move or you’ll screw everyone up and they will hate you.
Color code things, such as your notes. If you want to see how I color code my notes message me and I’ll be happy to show you. 
Be kind to one another.
I think that about does it. So yeah:)



HOLY SHIT SO MUCH OF THIS IS USEFUL

freedomforwhales:

im5-official:

Ahh yes, The dreaded school. When it comes around we all dread, new teachers, new schedule, some new unfamiliar faces, the MASSIVE amount of homework load, less time on tumblr. Here is another long post with a few sites and others to help you out here!

College needs:

Food

Helpful sites:

High school needs:

Mental health resources:

Misc resources:

Motivation:

Music/Sound:

School resources:

Stress relief:

Studying/school help:
English/History:

Foreign Languages:

Geography:

Math/Science:

Study Needs:

TIPS:

  1. Remember that today’s day in age is different from how it was back then. So don’t stress about school too much.High school students today have the anxiety of what a mental patient in the insane asylum had in the 50s. Here’s also a thing to show how times have changed.
  2. Prioritize. List what needs to get done first and when. Sometimes getting the bigger/harder tasks is easier than conquering the smaller/easier tasks.
  3. Set times when certain projects need to be done and stick to that deadline.
  4. Turn your phone off or give it to your parents while doing work/studying. I know that we live in the age of technology and literally everything is at the touch of our fingertips. Honestly though you can wait on what your favorite celebrity has to say or if your crush liked your instagram photo. You’ll be more involved in that than you are into your work.
  5. If you have trouble in a certain subject and there is no assigned seating, take advantage of the front. I guarantee you’ll learn more.
  6. Ask your teacher what exactly you’ll need to know. If you’re taking notes during the year, write in the margins whether or not it will be tested. It will be easier to know what you will be tested on.
  7. Save your exams. Half the time your teachers use the same questions (or questions similar) from your exams on your midterms or finals.
  8. Don’t try to do homework straight afterschool if you can’t, despite what everyone says. Give yourself an hour, and try to get some exercise in. I find it stops me getting bored of sitting down. Not to mention helps me concentrate better.
  9. Don’t just read the material, write it, draw it, recite it, quiz yourself on it! Until you have the material down.
  10. Join clubs, sports, or organizations! You’re guaranteed to find friends in there. You’ll already have common interests. Start with that and go with the flow.
  11. College kids: If you don’t have assigned seating, and you have been sitting in the same seat for 2 weeks. That is you assigned seat now. Don’t move or you’ll screw everyone up and they will hate you.
  12. Color code things, such as your notes. If you want to see how I color code my notes message me and I’ll be happy to show you
  13. Be kind to one another.

I think that about does it. So yeah:)

HOLY SHIT SO MUCH OF THIS IS USEFUL

Filed under school reference important masterpost

247 notes

Anonymous asked: Hello Boggle! Haven't heard from you in awhile, and just wanted to make sure that you're doing okay! I miss your happy owl-ness on my dash! :D

boggletheowl:

Hi anon! I am hanging in there. I am switching antidepressants right now, which has been kind of an adventure. Venlafaxine withdrawal has given me a whole new level of compassion for people struggling with addiction. 

I’ve had to take a break from work, which has been pretty dispiriting, but with my depression being such a bear to wrestle and being between medications, it was either take a break, or see my work become untenably unreliable. But I’m lucky: my boss is a very kind person who understands what I’m going through, and he has made it clear that he supports me and that my job will be waiting for me. A year ago I would not have been able to imagine being in a professional situation where I would feel confident that I could be honest with my boss about my troubles without reprisal! Thank you, to everyone at SciShow, for creating such a compassionate environment. =D

Lately I’ve just been trying to keep my moods on an even keel, and find things to occupy myself that help buoy me up. Depression can be so suffocating that I’m grateful for anything that gives me a little space to breathe. I’ve gotten super into a new online community (anybody play Flight Rising? I’m in Light!) where the people are incredibly nice, and even have mature and open and supportive discussions about mental health.

So I guess I just mean to say: I am doing as well as can be expected! I hope you guys are fighting the good fight too. 

Great to hear from you Boggle!

Keep fighting the fight! We’re all cheering for you! :D

62 notes

orcadiva:

The depression behind Kiska’s blowhole has gotten worse. When an orca has what some call “peanut head” it generally means they are severely underweight, sickly or near death. Something is seriously wrong with Kiska.
Please take some time to call the following to voice your concerns and to report suspected animal abuse: Ontario SPCA: 310-SPCA(7722) or email: cruelty@ospca.on.ca
Plus on Wednesday August 6th between 10am to 5pm there will be a demo outside the OSPCA at 16586 Woodbine Ave. RR3, Newmarket, Ontario L3Y 4W1

:( Poor thing.

orcadiva:

The depression behind Kiska’s blowhole has gotten worse. When an orca has what some call “peanut head” it generally means they are severely underweight, sickly or near death. Something is seriously wrong with Kiska.

Please take some time to call the following to voice your concerns and to report suspected animal abuse:
Ontario SPCA: 310-SPCA(7722) or email: cruelty@ospca.on.ca

Plus on Wednesday August 6th between 10am to 5pm there will be a demo outside the OSPCA at 16586 Woodbine Ave. RR3, Newmarket, Ontario L3Y 4W1

:( Poor thing.

(via teamorkid)

Filed under killer whales orca kiska

152 notes

neurosciencestuff:

Study Links Autistic Behaviors to Enzyme
Fragile X syndrome (FXS) is a genetic disorder that causes obsessive-compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It is the most common inherited cause of mental impairment and the most common cause of autism.
Now biomedical scientists at the University of California, Riverside have published a study that sheds light on the cause of autistic behaviors in FXS. Appearing online today (July 23) in the Journal of Neuroscience, and highlighted also on the cover in this week’s print issue of the journal, the study describes how MMP-9, an enzyme, plays a critical role in the development of autistic behaviors and synapse irregularities, with potential implications for other autistic spectrum disorders.
MMP-9 is produced by brain cells. Inactive, it is secreted into the spaces between cells of the brain, where it awaits activation. Normal brains have quite a bit of inactive MMP-9, and the activation of small amounts has significant effects on the connections between neurons, called synapses. Too much MMP-9 activity causes synapses in the brain to become unstable, leading to functional deficits.
“Our study targets MMP-9 as a potential therapeutic target in Fragile X and shows that genetic deletion of MMP-9 favorably impacts key aspects of FXS-associated anatomical alterations and behaviors in a mouse model of Fragile X,” said Iryna Ethell, a professor of biomedical sciences in the UC Riverside School of Medicine, who co-led the study. “We found that too much MMP-9 activity causes synapses to become unstable, which leads to functional deficits that depend on where in the brain that occurs.”
Ethell explained that mutations in FMR1, a gene, have been known for more than a decade to cause FXS, but until now it has been unclear how these mutations cause unstable synapses and characteristic physical features of this disorder. The new findings expand on earlier work by the research group that showed that an MMP-9 inhibitor, minocycline, can reduce behavioral aspects of FXS, which then led to its use to treat FXS.
To further establish a causative role for MMP-9 in the development of FXS-associated features, including autistic behaviors, the authors generated mice that were missing both FMR1 and MMP-9. They found that while mice with a single FMR1 mutation showed autistic behaviors and macroorchidism (abnormally large testes), mice that also lacked MMP-9 showed no autistic behaviors.
“Our work points directly to MMP-9 over-activation as a cause for synaptic irregularities in FXS, with potential implications for other autistic spectrum disorders and perhaps Alzheimer’s disease,” said Doug Ethell, the head of Molecular Neurobiology at the Western University of Health Sciences, Pomona, Calif., and a coauthor on the study.
The research paper represents many years of bench work and effort by a dedicated team led by the Ethells. The work was primarily done in mice, but human tissue samples were also analyzed, with findings found to be consistent. Specifically, the work involved assessing behaviors, biochemistry, activity and anatomy of synaptic connections in the brain of a mouse model of FXS, as well as the creation of a new mouse line that lacked both the FXS gene and MMP-9.
FXS affects both males and females, with females often having milder symptoms than males. It is estimated that about 1 in 5,000 males are born with the disorder.
The Ethells were joined in the study by UCR’s Harpreet Sidhu (first author of the research paper), Lorraine E. Dansie, and Peter Hickmott. Sidhu and Dansie are neuroscience graduate students; Hickmott is an associate professor of psychology.
Next, the researchers plan to understand how MMP-9 regulates synapse stability inside the neurons. They also plan to find drugs that specifically target MMP-9 without side effects such as new tetracycline derivatives that are potent inhibitors of MMP-9 but lack antibiotic properties.
“Although minocycline was successfully used in clinical trial in FXS, it has some side effects associated with its antibiotic properties, such gastrointestinal irritation,” Iryna Ethell said. “We, therefore, plan to test new non-antibiotic minocycline derivatives. These compounds lack antibiotic activity but still act as non-competitive inhibitors of MMP-9 similar to minocycline.”

neurosciencestuff:

Study Links Autistic Behaviors to Enzyme

Fragile X syndrome (FXS) is a genetic disorder that causes obsessive-compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It is the most common inherited cause of mental impairment and the most common cause of autism.

Now biomedical scientists at the University of California, Riverside have published a study that sheds light on the cause of autistic behaviors in FXS. Appearing online today (July 23) in the Journal of Neuroscience, and highlighted also on the cover in this week’s print issue of the journal, the study describes how MMP-9, an enzyme, plays a critical role in the development of autistic behaviors and synapse irregularities, with potential implications for other autistic spectrum disorders.

MMP-9 is produced by brain cells. Inactive, it is secreted into the spaces between cells of the brain, where it awaits activation. Normal brains have quite a bit of inactive MMP-9, and the activation of small amounts has significant effects on the connections between neurons, called synapses. Too much MMP-9 activity causes synapses in the brain to become unstable, leading to functional deficits.

“Our study targets MMP-9 as a potential therapeutic target in Fragile X and shows that genetic deletion of MMP-9 favorably impacts key aspects of FXS-associated anatomical alterations and behaviors in a mouse model of Fragile X,” said Iryna Ethell, a professor of biomedical sciences in the UC Riverside School of Medicine, who co-led the study. “We found that too much MMP-9 activity causes synapses to become unstable, which leads to functional deficits that depend on where in the brain that occurs.”

Ethell explained that mutations in FMR1, a gene, have been known for more than a decade to cause FXS, but until now it has been unclear how these mutations cause unstable synapses and characteristic physical features of this disorder. The new findings expand on earlier work by the research group that showed that an MMP-9 inhibitor, minocycline, can reduce behavioral aspects of FXS, which then led to its use to treat FXS.

To further establish a causative role for MMP-9 in the development of FXS-associated features, including autistic behaviors, the authors generated mice that were missing both FMR1 and MMP-9. They found that while mice with a single FMR1 mutation showed autistic behaviors and macroorchidism (abnormally large testes), mice that also lacked MMP-9 showed no autistic behaviors.

“Our work points directly to MMP-9 over-activation as a cause for synaptic irregularities in FXS, with potential implications for other autistic spectrum disorders and perhaps Alzheimer’s disease,” said Doug Ethell, the head of Molecular Neurobiology at the Western University of Health Sciences, Pomona, Calif., and a coauthor on the study.

The research paper represents many years of bench work and effort by a dedicated team led by the Ethells. The work was primarily done in mice, but human tissue samples were also analyzed, with findings found to be consistent. Specifically, the work involved assessing behaviors, biochemistry, activity and anatomy of synaptic connections in the brain of a mouse model of FXS, as well as the creation of a new mouse line that lacked both the FXS gene and MMP-9.

FXS affects both males and females, with females often having milder symptoms than males. It is estimated that about 1 in 5,000 males are born with the disorder.

The Ethells were joined in the study by UCR’s Harpreet Sidhu (first author of the research paper), Lorraine E. Dansie, and Peter Hickmott. Sidhu and Dansie are neuroscience graduate students; Hickmott is an associate professor of psychology.

Next, the researchers plan to understand how MMP-9 regulates synapse stability inside the neurons. They also plan to find drugs that specifically target MMP-9 without side effects such as new tetracycline derivatives that are potent inhibitors of MMP-9 but lack antibiotic properties.

“Although minocycline was successfully used in clinical trial in FXS, it has some side effects associated with its antibiotic properties, such gastrointestinal irritation,” Iryna Ethell said. “We, therefore, plan to test new non-antibiotic minocycline derivatives. These compounds lack antibiotic activity but still act as non-competitive inhibitors of MMP-9 similar to minocycline.”

Filed under autism enzyme science

339 notes

whatevercactus:

How to save hardened paint brushes!

This has been one of the most
useful tips I have learned while in
college so I thought I would share
how I save paint brushes that I was
too lazy to clean out good enough
the first time.
  1. Step One: go buy murphy oil soap, or check your cabinets and look for it. I was surprised when I saw it sitting in my cabinet at home because I had no idea we actually used to clean our house. It’s pretty common to find in stores. You can buy it at dollar general for just a few bucks.
  2. Step Two: take your brushes that you have let become really hard because you either used glue in them, or acrylic paint. Soak them for as much time as possible! The more you let them soak, the easier it will be to work apart the bristles. I have let mine soak anywhere from 24 hours to 96 hours.
  3. Step Three: once you have let your brushes soak, rinse the brush under slow moving water, use your hands to move the bristles around.. all you are trying to see how much the murphy oil soap did on its own, and if it is still a little stiff you will want to let it soak some more.
  4. Step Four: I have a pinch pot I made in a ceramics class to be able to wash my brushes. It doesn’t have to be anything fancy, but it does need to be textured! I drew patterns on the side so I could rub my brushes to make bristles start working in different directions. 
  5. Step Five: after you loosened the bristles by rubbing it on something textured, dip them back in the murphy oil soap and rub it a few more times on the textured surface. this allows the soap to get in all of the new openings in your paint brush.
  6. Step Six: rise it out with the bristles facing down so that anything hard comes out of your brush instead of staying up in the top. You should really use your hands a lot in this step to make sure any glue or paint chips are out.
  7. Step Seven: put a little bit more soap on the brush with a little bit of water, only dampening the bristles. leave it like that until the next time you want to use the brush, and it should be like new.
Bonus to this reference post:
one of my professors used murphy's to
get paint stains out of clothes. 

(via ibelievepracticemakesperfect)

Filed under art painting reference

3 notes

Okay, depression, here’s the deal.

I enjoy my life. I enjoy what I do.

All of it.

You are annoying.

And I am going to enjoy my life despite your kicking and screaming and dementor-like energy suckingness.

k thanks bye

Filed under depression

214,818 notes

joose420:

darklordflareon:

liongirl5:

dennys:

Flaphack #7: *Magically transform an old concert lanyard into a soothing pancake scented car freshener! 
*not actually magic

DENNY’S WHAT THE HELL ARE YOU EVEN DOING

denny’s has the best social media marketing team ever look at this look at itthey knew their restaurant was the equivalent of 3am nightblogging and they just went with it

The best part is that it totally works.

joose420:

darklordflareon:

liongirl5:

dennys:

Flaphack #7: *Magically transform an old concert lanyard into a soothing pancake scented car freshener! 

*not actually magic

DENNY’S WHAT THE HELL ARE YOU EVEN DOING

denny’s has the best social media marketing team ever look at this look at it

they knew their restaurant was the equivalent of 3am nightblogging and they just went with it

The best part is that it totally works.

(via therealraewest)

Filed under dennys lolz